Docs Nov '09 - Questions

MIZBELLA wrote:

MIZBELLA wrote:

mom_in_il wrote:

MIZBELLA wrote:

The_Thinker wrote:

mom_in_il wrote:So Caylee could have been dosed with grandma's meds. How sad is that . . .

It would be sad .... but the Lab said that Cindy's Clonazepam (muscle relaxant) was NOT detected in Caylee's hair mass. Neither was Alprazolam/Xanax detected.

The Cepuroxime is a strong antibiotic.
Protonix is for acid reflux

But what if the day Caylee died was the first time she was dosed with the Clonazepam? If she was dosed only one time, I don't think that it would be detected in the hair mass.

Time for your expert opinion Miz! What would an adult dose of clonazepam do to an almost three year old?

Let me check with the RN I work with and I will get back to you....I also need to find out what the dose was that Cindy was taking and the Milligrams. Be back with and answer soon.

Single oral dose administration of clonazepam to humans gave maximum
blood levels of drug, in most cases, within one to two hours.
Interference with Cognitive or Motor Performance:
Since clonazepam produces CNS depression, patients receiving this drug
should be cautioned against engaging in hazardous occupations requiring
mental alertness, such as operating machinery or driving a motor
vehicle. They should also be warned about the concomitant use of
alcohol or other CNS-depressant drugs during clonazepam therapy.
Usage in Children:: Because of the possibility that
adverse effects on physical or mental development could become apparent
only after many years, a benefit-risk consideration of the long-term
use of clonazepam is important in pediatric patients.

Clonazepam may produce an increase in salivation. This should be
considered before giving the drug to patients who have difficulty
handling secretions. Because of this and the possibility of respiratory
depression, clonazepam should be used with caution in patients with
chronic respiratory diseases. Experience to date has shown that drowsiness has occurred in approximately 50% of patients. Neurologic: Abnormal eye movements, aphonia,
choreiform movements, coma, diplopia, dysarthria, dysdiadochokinesis,
"glassy-eyed" appearance, headache, hemiparesis, hypotonia, nystagmus,
respiratory depression, slurred speech, tremor, vertigo.Respiratory: Chest congestion, rhinorrhea, shortness of breath, hypersecretion in upper respiratory passages.
Overdose


Signs and Symptoms
Symptoms of clonazepam overdosage, like those produced by other CNS
depressants, include somnolence, confusion, coma and diminished
reflexes.
Adults: The initial dose for adults should not exceed
1.5 mg/day divided into three doses. Dosage may be increased in
increments of 0.5 to 1 mg every three days until seizures are
adequately controlled or until side effects preclude any further
increase. Maintenance dosage must be individualized for each patient
depending upon response. Maximum recommended daily dose is 20 mg.

Children: Clonazepam is administered orally. In order
to minimize drowsiness, the initial dose for infants and children (up
to 10 years of age or 30 kg of body weight) should be between 0.01 and
0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three
divided doses. Dosage should be increased by no more than 0.25 to 0.5
mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg
of body weight has been reached unless seizures are controlled or side
effects preclude further increase. Whenever possible, the daily dose
should be divided into three equal doses. If doses are not equally
divided, the largest dose should be given before retiring.

Chemically, clonazepam is 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has a molecular weight of 315.72 and the following structural formula:

Clonazepam is a Schedule IV controlled substance.



Ok, this is what I have come up with doing my own research....I don't think I have to explain what 2 - 0.5 mg which is the equivalent of 1mg of clonazepam would do to a 2 year old, especially since clonazepam is not recommended for children under 18 unless special conditions permit..ie...severe seizure disorders, which we all know Caylee did not have, by Cindy's own admission Caylee was a healthy 2 1/2 year old. In the event that ESOTD did dose Caylee with 2- 0.5mg doses of Clonazepam, Caylee would have become extremely drowsy and ultimately Caylee's respirations would have slowed down and she would have stopped breathing. I don't think I need to explain more and of all the scenarios of how Caylee died, I pray this is how it happened because she would not have been in pain and she probably would have went to sleep never to awake. I did talk to my RN friend who confirmed my research, but this was after she ask me " Who the hell is giving a 2 1/2 year old klonopin".... she also said if Clonazepam is give at this young age for seizures the pill is scored and 0.5mg would be split into peices and given at different intervals through out a day so the child was not overdosed...even if Caylee was given 0.5mg and not 1mg, it still could have been enough to slow her respirations down and slow her heart to the point of death. My friend said it is rare a child is given clonazepam and if they are it is monitored so very close and only is usually given in doses of 0.01-0.03mg a day up to but rarely 0.5mg.....0.5mg is the max dose for a child who has severe seizures and is not generally recommended for a child younger than 10....So "yes" I believe if Caylee was given a single adult dose of 0.5mg of clonazepam it could very well be what killed her. And I also asked about hair mass and My friend said they tested the skin(scalp) that was attached to the hair, and that is where they probably detected the clonazepam in trace amounts, it would not have been in her hair like thc would be unless it was given over a prolonged period of time. I'll see what else I can dig up and in the meantime find me "more"



Oh'' I almost forgot....
Somnolence (or "drowsiness") is a state of near-sleep, a strong desire for sleep, or sleeping for unusually long periods (c.f. hypersomnia).
It has two distinct meanings, referring both to the usual state
preceding falling asleep, and the chronic condition referring to being
in that state independent of a circadian rhythm.
The disorder characterized by the latter condition is most commonly
associated with the use of prescription medications such as mirtazapine or zolpidem.

kiwimom wrote:

mom_in_il wrote:Is this the second blanket, the pink blanket?

I don't think so Mom. The Koala Baby brand seem to be smaller and the one found near Caylee has a purple and pink flower pattern. Here's a link to some.
http://www.thefind.com/family/browse-Koala-Baby-Blankets

kiwimom wrote:Someone posted on Sheaffers blog about the results of liquid from the Crystal Light found in the car. I'm so confused. These docs are all over the place. Q241 is the tag. A vial of the liquid was sent for testing. The comment made was that it smelled like urine and later in the docs it says after a phone call with Savage no further testing was ordered. However, there are results where it contained the following;

MeOH (this can be used in antifreeze, solvent, fuel)
Methyl Ethyl Ketone (Used in laquer, varnishes, paint remover and glues)
2 - Butanol (Industrial cleaners, pain removers)
Dimethyl Disulfide (Solvent, pesticides)
Anisole (a fragrance for chemicals, perfumes)
p-cresol ( pesticides, in Lysol)

The doc numbers that relate to this Q241 are 11481, 11523, 11553(the chemical breakdown) and 11985(the summary about phone call). It's interesting that in this comment, it says Q241 negative for chloroform but nowhere in the docs can I find a comment describing what it was. It doesn't confirm urine or anything and there is no explanation about these deadly chemicals.

kiwimom wrote:Someone posted on Sheaffers blog about the results of liquid from the Crystal Light found in the car. I'm so confused. These docs are all over the place. Q241 is the tag. A vial of the liquid was sent for testing. The comment made was that it smelled like urine and later in the docs it says after a phone call with Savage no further testing was ordered. However, there are results where it contained the following;

MeOH (this can be used in antifreeze, solvent, fuel)
Methyl Ethyl Ketone (Used in laquer, varnishes, paint remover and glues)
2 - Butanol (Industrial cleaners, pain removers)
Dimethyl Disulfide (Solvent, pesticides)
Anisole (a fragrance for chemicals, perfumes)
p-cresol ( pesticides, in Lysol)

The doc numbers that relate to this Q241 are 11481, 11523, 11553(the chemical breakdown) and 11985(the summary about phone call). It's interesting that in this comment, it says Q241 negative for chloroform but nowhere in the docs can I find a comment describing what it was. It doesn't confirm urine or anything and there is no explanation about these deadly chemicals.

• Chloroform should always be handled by qualified persons or under qualified supervision.
  
• Children and pets should NEVER be allowed to come close to the [color:40d5=blue ! important][color:40d5=blue ! important]chemical.
  
• Always wear protective gear and follow safety practices when handling chloroform.
  
• Chloroform reacts with oxygen to make phosgene, a chemical gas
  which when consumed causes irreparable damage to your body organs.
  Chloroform also turns into phosgene faster under direct sunlight
  (radiation).
  

• Always store in an amber or brown glass bottle and NOT in plastic or metal containers
  
• To store all the way up to the top
  
• To store it for not longer than a week as it will start decomposing.
  
• Never inhale chloroform made in the manner given below.
  

• Bleach
  
• Pure acetone, which is available at hardware stores
  
• Ice
  
• Glassware, which will allow [color:40d5=blue ! important][color:40d5=blue ! important]clear [color:40d5=blue ! important]vision of the solution inside
  
• Separation funnel
  

• Start by filling up a glass container with half a liter of bleach
  
• Lower the temperature of the bleach solution by adding ice also into the container and allowing it to cool.
  
• Pour 10 ml of the acetone (to maintain a ratio of 1: 50, one part acetone to fifty parts of bleach) into the container.
  
• Add some more ice to keep the temperature low. Replacing the cubes
  that have already melted will ensure this. The bleach must be kept cool
  as otherwise it will emit fumes of bleach and chloroform.
  
• Keep aside for 20 minutes to ensure complete reaction. In a while clouding up can be seen with an increase in temperature.
  
• Allow time for the reaction to settle. This will take about half an
  hour, but if after this time also the solution does not appear to be
  settling, a stir will help.
  
• Once settled, you will see either be a white powder residue or a bubble at the bottom. This is chloroform.
  
• Pour the solution out with care ensuring that no powder or bubble leaves the container.
  
• Now, the pure chloroform, which remains in the glass container, can be extracted with a separation funnel.
  

momgot2kids wrote:This is the MSDS on Chloroform
http://polymer.matscieng.sunysb.edu/msds/chloroform.pdf

The MSDS is required for every chemical make up in this country all available online. Very few people know about this unless you deal with chemicals on a routine bases as we do, I am required to log everything purchased, sprayed, location etc. also have a statewide list we receive every quarter of people and areas that have to be notified 48 hrs before spraying can happen with a 1 mile radius of there home.

Hope this helps